Has anyone succeeded in getting the configure script for R to use Goto's BLAS? This library, usually configured to be -lgoto, is an implementation of the BLAS that can be significantly faster than atlas. At present it is freely available for some architectures at http://www.cs.utexas.edu/users/flame/goto/ However, it is not open source. You must install it yourself and you cannot redistribute it. I was able to compile a version of R using -lgoto by tweaking the Makeconf file after it was generated by configure and before running make. On a naive test mm = matrix(rnorm(1e6), nc = 1e3) system.time(crossprod(mm)) # repeat the last call until the execution time stabilizes I found that the execution time with -lgoto was about 80% of the execution time for -lf77blas -latlas on this machine (Pentium 4, 512 KB L2 cache). One caveat, my version of atlas is somewhat out of date.