Hi, I have exactly the same problem with R 2.4.1 on an Intel MacBook with Mac OS X 10.4.8. Please find below the output of the test. Christophe --- > source("/Users/Christophe/Desktop/Rdynunload/run.R") WARNING: ignoring environment value of R_HOME gcc-4.0 -arch i386 -I/Library/Frameworks/R.framework/Resources/ include -I/Library/Frameworks/R.framework/Resources/include/i386 - msse3 -D__NO_MATH_INLINES -fPIC -g -O2 -std=gnu99 -march=nocona -c code.c -o code.o gcc-4.0 -arch i386 -dynamiclib -Wl,-macosx_version_min -Wl,10.3 - undefined dynamic_lookup -single_module -multiply_defined suppress -L/ usr/local/lib -o foo.so code.o -L/Library/Frameworks/R.framework/ Resources/lib/i386 -lR -dylib_file libRblas.dylib:/Library/Frameworks/ R.framework/Resources/lib/i386/libRblas.dylib [1] "Failed" loaded DLL/SO WARNING: ignoring environment value of R_HOME gcc-4.0 -arch i386 -I/Library/Frameworks/R.framework/Resources/ include -I/Library/Frameworks/R.framework/Resources/include/i386 - msse3 -D__NO_MATH_INLINES -fPIC -g -O2 -std=gnu99 -march=nocona -c other.c -o other.o gcc-4.0 -arch i386 -dynamiclib -Wl,-macosx_version_min -Wl,10.3 - undefined dynamic_lookup -single_module -multiply_defined suppress -L/ usr/local/lib -o foo.so other.o -L/Library/Frameworks/R.framework/ Resources/lib/i386 -lR -dylib_file libRblas.dylib:/Library/Frameworks/ R.framework/Resources/lib/i386/libRblas.dylib first attempt loaded DLL/SO first attempt ---