wine users - May 2011 - Natural Motion Endorphin LE on Wine 1.2.2

I am using Ubuntu 10.10 and I installed Endorphin. When I Open it it shows the
opening logo like it should, then it closes out like it should. But after that
the actual program never opens. Please help.

First thing - upgrade Wine. The latest Wine version is wine-1.3.19. Then make
sure your video drivers are correctly installed.

Follow the instructions in the app db:
http://appdb.winehq.org/objectManager.php?sClass=version&iId=10754