similar to: R vs. Splus in Pharma/Devices Industry

I would like to use R for submissions to FDA/CDRH (the medical device company I work for currently uses only SAS). Previous postings to the list regarding R and 21 CFR 11 compliance have been very helpful. However, reluctance to using open source software for statistical analyses and reporting remains high here at my company. Has anyone used R for an official submission to FDA/CDRH? It would

Does anyone know if for clinical studies the FDA would accept statistical analyses performed with R ? Delphine Fontaine

Dear All, discussing with a statistician of a pharmaceutical company I received this answer about the statistical package that I have planned to use: As R is not a validated software package, we would like to ask if it would rather be possible for you to use SAS, SPSS or another approved statistical software system. Could someone suggest me a 'polite' answer? TIA Giovanni -- dr.

I am new to using R and would appreciate some advice on which books to start with to get up to speed on using R. My Background: 1-C# programmer. 2-Programmed directly using IMSL (Now Visual Numerics). 3- Used in past SPSS and Statistica. I put together a list but would like to pick the "best of" and avoid redundancy. Any suggestions on these books would be helpful (i.e. too much

I am running R version 2.4.1 on Windows XP. I have a question regarding the datadist() function from the Design library. I have a data.frame (call it my.data) with 4 columns. When I submit the code datadist(data=my.data) I get the following error message: Error in X[[1]] : subscript out of bounds I suspect there may be something wrong with my data.frame (I'm certain there is nothing

Hi all, The survivals functions can be tested by the Log-rank test and others, for example the Gehan-Breslow. The graham breslow work with the alpha values. But I don't know how is the Gehan-Breslow test with R. Somebody know a type function?.. or other suggestions? Any help will be really appreciated Jos? Bustos Marine Biologist Master Apllied Stat Program University of Concepci?n

Hi all there Can some one who have experience and knowledge in the pharma industry give me broad details on the subject "Statistical applications for pharma industry". I am new to the subject i.e. what kind of statistical tools used being unique /or atleast specific for pharma industry. It will be of great help as i am actively looking into the subject. though i am quite familiar

Does anyone know of an R function for computing the Greenland-Robins variance for Mantel-Haenszel relative risks? Thanks Frank -- Frank E Harrell Jr Professor and Chair School of Medicine Department of Biostatistics Vanderbilt University

Dear all, There have been a variety of discussions on the R list regarding the use of R in clinical trials. The following post from the STATA list provides an interesting opinion regarding why SAS remains so popular in this arena: http://www.stata.com/statalist/archive/2008-01/msg00098.html Regards, -Cody Hamilton

Hello, I might be barking up the wrong tree here, but I want to make sure I have a full understanding of this. What I would like to know is what tests are performed to give the p-values for each variable in the table that is the result of coxph regression when the variables are categorical only. More specifically, when expected counts are less than 5 is the Fisher's exact test used instead

Hello. I would like to estimate the correlation coefficient from two samples with Bootstrapping using the R-function sample(). The problem is, that I have to sample pairwise. For example if I have got two time series and I draw from the first series the value from 1912 I need the value from 1912 from the second sample, too. Example: Imagine that a and b are two time series with returns for

Hello, I have a basic problem but i can't figure it out with the table underneath. I would like to compute monthly averages. I would like to have the average measure for month #5 for the first three rows (the same number in the first three lines) and the average measure for month #6 for the last four rows ((the same number in the first three lines) in a separate vesctor (let's call

Hi, Im getting the following error when I attempt to read a csv file into R. I have the file saved on my C drive. Id really appreciate it if anyone can help.... My Command: > survey <- read.csv (file = "C:\onlinesurvey.csv",head= TRUE, sep =",") Error: Error in file(file, "r") : unable to open connection In addition: Warning messages: 1: '\o' is an

Is there a way to create a 'bubble plot' in R? For example, if we define the following data frame containing the level of y observed for 5 patients at three time points: time<-c(rep('time 1',5),rep('time 2',5),rep('time 3',5))

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Hi All, We're interested in finding other users of R in pharmaceutical companies. Please reply if you are or know of someone who is. -Greg Gregory R. Warnes, Ph.D. Pfizer Global Research and Development LEGAL NOTICE Unless expressly stated otherwise, this message is confidential and may be privileged. It is intended for the addressee(s) only. Access to this E-mail by anyone else is

I've just finished an Xcode 3.1 project file for flac and metaflac that builds both tools as 32/64 bit universal binaries. If anyone is interested in either the binaries or the project, I'll be happy to share them. Stephen

Hello All, Have recently started learning Sweave and Knitr. Am now trying to learn odfWeave as well. Things went pretty smoothly with Sweave and Knitr but I'm having some trouble with odfWeave. My understanding was that odfWeave should work in pretty much the same way as Sweave. With odfWeave, you set up an input .odt file in a folder, run that file through the odfWeave function, and then

Dear all, I am doing my first steps with odfWeave. After running the r code (see below), I am trying to open the ODF-document with open office, but I am getting the error message: "The file is damaged, but it can be repaired". If I confirm the question and repair the file with open office, I can open it with the desired output, which seems to be fine. My system: R Version 2.9.1

Hello I tried the odfWeave package today, by running the formatting.odt and example.odt files that are included with the package. They both ran fine, but when I try to open them in my OpenOffice (OpenOffice 3.1.1 on Kubuntu 9.10) I get an error "Format error discovered in the file in sub-document content.xml at 1293,124(row,col)." I also tried to open them in MS Word 2003 (Windows