similar to: Random Coefficients using coxme

Hi there, I have a question on fitting data by coxme. In particular I want to fit a random intercept and random slope cox model. Using the rats dataset as an example, I generated another covariate x2 and want to specify a random slope for x2. Here is my code: x2=matrix(rep(runif(50), 3), 50, 3) x2=as.vector(t(x2)) rats2=cbind(rats, x2) But when I used the coxme function as follows, it gave

Dear all, I am using "coxme" function in Kinship library to fit random treatment effect nested within centre. I got 3 treatments (0,1,2) and 3 centres. I used following commands, but got an error. > ugroup=paste(rep(1:3,each=3),rep(0:2,3),sep='/') > mat1=bdsmatrix(rep(c(1,1,1,1,1,1,1,1,1),3),blocksize=rep(3,3),dimnames=list(ugroup,ugroup)) >

Dear R users: I'm new to R and am trying to fit a mixed model Cox regression model with coxme function. I have one two-level factor (treat) and one covariate (covar) and 32 different groups (centers). I'd like to fit a random coefficients model, with treat and covar as fixed factors and a random intercept, random treat effect and random covar slope per center. I haver a couple of

I've finally narrowed down a puzzling problem: here is the short test case. tmt34% R --vanilla R version 2.10.0 (2009-10-26) Copyright (C) 2009 The R Foundation for Statistical Computing ISBN 3-900051-07-0 > temp <- matrix(runif(50), ncol=2) > t(temp) %*% temp [,1] [,2] [1,] 7.916016 6.049698 [2,] 6.049698 7.650694 > library(kinship) Loading required package:

Dear all, I have encountered the following problem where coxme seems to allow model with only random effect in R 2.11.1 but not in R 2.13.0. Following is the error message using rat example data. Any comment on this is appreciated. In R2.13 > library(coxme) > rat1 <- coxme(Surv(time, status) ~ rx + (1|litter), rats) > rat0 <- coxme(Surv(time, status) ~ (1|litter), rats)

I'm currently packaging up some of the kinship matrix routines more formally, these are used in coxme when dealing with family correlation structures. One of my test programs exercises error conditions, i.e., it purposely feeds particular types of invalid pedigree data in to see if the right error message results. So there are comment-action pairs # the next line should generate a

The package coxme depends heavily on bdsmatrix, to the point of needing access to some of its C calls. The kinship package (in progress) uses the R level functions in bdsmatrix, but not the C calls. That is, I don't want to always export the symbols. For testing I can use an explicit dyn.load('somepath/bsdmatrix.so', local=F). How do I incorporate such a dependency in the

Dear all, This probably stems from my lack of understanding of the model, but I do not understand the variance of the random effect reported in coxme. Consider the following toy example: #------------------------------- BEGINNING OF CODE ------------------------------------------------ library(survival) library(coxme) #--- Generate toy data: d <- data.frame(id = c(1:100), #

Hi I'm encountering some problems with coxme My data: I'm looking at the survival of animals in an experiment with 3 treatments, which came from 4 different populations, two of which were infected with a parasite and two of which were not. I'm interested if infected animals differe from uninfected ones across treatments. Factor 1: treatment (3 levels) Factor 2: infection state

Hi I would really appreciate some help with my code for coxme... My data set I'm interested in survival of animals after an experiment with 4 treatments, which was performed on males and females. I also have two random factors: Response variable: survival (death) Factor 1: treatment (4 levels) Factor 2: sex (male / female) Random effects 1: person nested within day (2 people did

Dear R experts; I am trying to extract the p values from a coxme object (package coxme). I can see the value in the model output, but I wanted to have the result with a higher number of decimal places. I have searched the mailing list and followed equivalent suggestions for nlme/lme objects, but I wasn't successful. Thanks; Catarina [[alternative HTML version deleted]]

Hello, and thanks for your time I'm trying to extract standard errors to produce confidence intervals from a multivariable coxme model object so I can write a function that will print a summary for some reproducible research. As far as I can glean, the SE is produced on-the-fly by the print method. I'll dig into the source code if I have to, but I'd rather not have to. Any help

Dear List, In documents (Therneau, 2003 : On mixed-effect cox models, ...), as far as I came to know, coxme penalize the partial likelihood (Ripatti, Palmgren, 2000) where as frailtyPenal (in frailtypack package) uses the penalized the full likelihood approach (Rondeau et al, 2003). How, then, coxme and coxph(...frailty(id, dist='gauss')) differs? Just the coding algorithm, or in

Hello, All, GWAF 1.2 R.Version() is below. system(lme.batch.imputed( phenfile = 'phenfile.csv', genfile = 'CARe_imputed_release.0.fhsR.gz', pedfile='pedfile.csv', phen='phen1', covar=c('covar1','covar2'), kinmat='imputed_fhs.kinship.RData', outfile='imputed.FHS.IBC.GWAF.LME.output.0.txt' )) Gives the error messages: Error in

Version 2.2 of coxme has been posted to CRAN, Windows versions and mirrors should appear in due course. This is a major update with three features of note: 1. A non-upwardly compatable change: Extractor functions: beta= fixed effects, b=random effects nlme lme4 coxme <2.2 coxme 2.2 lmekin 2.2 ------------------------------------------------------ beta

Hello, I am running R 2.6.1 on windows xp I am trying to fit a cox proportional hazard model with a shared Gaussian frailty term using coxme My model is specified as: nofit1<-coxme(Surv(Age,cen1new)~ Sex+bo2+bo3,random=~1|isl,data=mydat) With x1-x3 being dummy variables, and isl being the community level variable with 4 levels. Does anyone know if there is a way to get the standard error

Dear R users, I'm using the function coxme of the package coxme in order to build Cox models with complex random effects. Unfortunately, I sometimes get surprising estimations of the variances of the random effects. I ran models with different fixed covariates but always with the same 3 random effects defined by the argument varlist=coxmeMlist(list(mat1,mat2,mat3), rescale = F, pdcheck = F,

I am making the question clear. Please help. > Dear R experts > > I was using kinship package to fit mixed model with kinship matrix. > The package looks like lme4, but I could find a way to extract p-value > out of it. I need to extract is as I need to analyse large number of > variables (> 10000). > > Please help me: > > require(kinship) > > #Generating

Dear list, I have been trying to use coxme in R 2.3.1. When I use coxme in the following data sim.fr1, i get "Warning messages: using 'as.environment(NULL)' is deprecated" Why does it occur? How can I hide such warning message, especially when coxme is under a loop? Mohammad Ehsanul Karim (Institute of Statistical Research and Training, University of Dhaka) >

Hi, I am new to R and AIC scores but what I get from coxme seems wrong. The AIC score increases as p-values decrease. Since lower AIC scores mean better models and lower p-values mean stronger effects or differences then shouldn't they change in the same direction? I found this happens with the data set rats as well as my own data. Below is the output for two models constructed with the rats