similar to: Multiple endpoint (possibly group sequential) sample size calculation

Hello Everyone,   I’m a SAS user who has recently become interested in sequential clinical trials designs. I’ve discovered that the SAS based approaches for these designs are either too costly or are “experimental.” So now I’m looking for alternative software. Two programs that seem promising are SPLUS Seqtrial and R.   I recently obtained a 30 day trial for the SPLUS Seqtrial add-on and have

Nonclinical Biostatistics position at Genentech, South San Francisco September 3, 2009 Genentech has an opening for a full time position in its Nonclinical Biostatistics group, located in South San Francisco, CA. The nonclinical group currently consists of ten MS and PhD level statisticians and mathematicians, plus one programmer, who work with approximately 1,000 scientists, engineers, and

July 14, 2011 Genentech, A Member of the Roche Group, has an opening for a full time position in its nonclinical biostatistics group located in South San Francisco, CA. The nonclinical group consists of statisticians who work with scientists, engineers, and managers in research, drug discovery, preclinical testing, process and product development, manufacturing, and quality control. Statistical

Sorry for messed up text. Here it goes again: I am learning to use the gsDesign package. I have a question about Pocock and OBF boundary. As far as I can understand, these 2 boundaries require equal spacing between interim analyses (maybe this is not correct?). But looks like I can still use gsDesign to run an analysis based on unequal spacing:? >

Hi All: I am working with a dataset on Arsenic toxicity, and I am trying to calculate the 20th, 40th, 60th, 80th, and highest percentiles for a variable, dietary Moisture (variable name dMoist). The inbuilt function quantile(dMoist) would print 0, 25th, 50th, 75th, and 100th percentile. Does there exist a function that can calculate xth percentile (where x = 10th, 20th, ... etc) values?

Hi, I am learning to use your gsDesign package!?I have a question about Pocock and OBF boundary. As far as Iunderstand, these 2 boundaries require equal spacing between interim analyses(maybe this is not correct?). But I can still use gsDesign to run an analysisbased on unequal spacing:?gsDesign(k=2,test.type=2,timing=c(0.75,1),alpha=0.05,sfu='Pocock')Symmetrictwo-sided group sequential

Hello. I'm a distro maintainer and was wondering about the efficacy of entropy daemons like haveged and jitterentropyd in qemu-kvm. One of the authors of haveged [0] pointed out if the hardware cycles counter is emulated and deterministic, and thus predictible. He therefore does not recommend using HAVEGE on those systems. Is this the case with KVM's counters? PS. I will be setting VM CPU

Still failed. The first secret is in your email program settings, to use Plain Text format (at least for emails you send to this mailing list). The second secret tool to use is the reprex package to let you verify that your code example will do on our computers what it is doing on your computer before you send it to us. That will also involve giving us some sample data or referencing some data

> On 23 Sep 2017, at 01:32, array chip via R-help <r-help at r-project.org> wrote: > > Hi, > > I am learning to use your gsDesign package! I have a question about Pocock and OBF boundary. As far as Iunderstand, these 2 boundaries require equal spacing between interim analyses(maybe this is not correct?). But I can still use gsDesign to run an analysisbased on unequal

I hope that this job posting does not offend anyone. My sincere apologies if it is inappropriate -- blame me, not my company. -- Bert Gunter Genentech Nonclinical Statistics South San Francisco, CA Genentech has an opening for a fulltime position in its nonclinical biostatistics department, located in South San Francisco, CA. The nonclinical group currently consists of seven MS and PhD

I'd like to produce a series of simple line graphs for my methods class that show the three questions used on a repeated survey to make up a particular index. The data frame is: > efficacy.df year complicated havesay dontcare 1 1952 71 68 63 2 1954 NA NA NA 3 1956 64 71 71 4 1958 NA NA NA 5 1960

Dear R users, I d like to assess the effect of "treatment" covariate on a disease relapse risk with the package cmprsk. However, the effect of this covariate on survival is time-dependent (assessed with cox.zph): no significant effect during the first year of follow-up, then after 1 year a favorable effect is observed on survival (step function might be the correct way to say that ?).

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hi! i have a small problem with the game, my energy is black and toxicity too. Can you help me?

On Sat, Sep 5, 2009 at 5:51 PM, Chris Lattner<clattner at apple.com> wrote: > > On Sep 5, 2009, at 1:53 PM, Nick Lewycky wrote: > >> A recent commit added the ability to opt and llc to read .ll files >> directly. Should we go through and update the existing tests? > > Yes, I think that Dan is planning to do this. ... and it is definitely worth doing. On my system

I tried to post this a few times last week and it seems to have got stuck somehow so I'm trying from a different email in the hope that works. If somehow this has appeared on the list 20 tiems and I never saw any of them I apologize ;-) I'm basically an R-newbie. But I am VERY computer literate. But this has me stumped... All the examples for using the rmeta package to create a

Hi R experts, I have a data recoding problem I cant get my head around - I am not that great at the subsetting syntax. I have a dataset of longitudinal toxicity data (for multistate modelling) for which I want to also want to do a simple Kaplan-Meier curve of the time to first toxic event. The data for 2 cases presently looks like this (one with an event, the other without), with id representing

Martin Kletzander: > On Fri, Aug 10, 2018 at 08:33:00PM +0000, procmem wrote: >> Hello. I'm a distro maintainer and was wondering about the efficacy of >> entropy daemons like haveged and jitterentropyd in qemu-kvm. One of the >> authors of haveged [0] pointed out if the hardware cycles counter is >> emulated and deterministic, and thus predictible. He therefore does

I''d like to extend bleucloth or redcloth to support custom tags, e.g. I want to use markup like this: [pubmed:18332676] which shall be extended to: <a href="http://www.ncbi.nlm.nih.gov/pubmed/18332676">Behav Pharmacol. 2008 Mar;19(2):121-128.</a> Does anyone know, if this is possible and has some hints how to do this?! I have not decided, wether I want to use

Dear List, I recently asked about any R implementations of Whitehead's methods for sequential clinical trials. Here's the summary of answers so far : 1) There is no R public implementation of those methods 2) There exists an interest for such a package, which does things quite different from Lan-deMets paradigm (shortly : Whitehead's methods allows for unplanned interim analyses