similar to: Cox model

Dear list, I am trying to build a cox model and then perform ROC analysis in order to retrieve some genes that are correlated with breast cancer. When I calculate the hazard score taking into account different numbers of genes and their coefficients ( I am trying to find the pest predictor number of genes), I retrieve from around 1 values (for few genes included ) to size of e+80 values (for many

Dear list, I am trying to perform a significance analysis of a microarray experiment with survival data using the {samr} package. I have a matrix containing my data which has 17816 rows corresponding to genes, and 286 columns corresponding to samples. The name of this matrix is data.matrix2. Some of the first values of this matrix are: data.matrix2[1:3,1:5] GSM36777 GSM36778 GSM36779

Hello R users, I am trying to run a cox model for the prediction of relapse of 80 cancer tumors, taking into account the expression of 17000 genes. The data are large and I retrieve an error: "Cannot allocate vector of 2.4 Mb". I increase the memory.limit to 4000 (which is the largest supported by my computer) but I still retrieve the error because of other big variables that I have in

Dear friends: I'm interested to make a stacked plot of cumulative incidence. that's, the cuminc model is fitted [fit=cuminc(time, relapse)] and cumulative incidence is in place. I'd like to stack the cuminc plots (relapse of luekemia and death free from leukemia, for example) , then the constituent ratio of leukemia relapse and treatment related mortality is very clear. Can

Dear list, I am not familiar with survival analysis and I would need your help to understand a result I have obtained. I have used the following command line to look at number of events and probability of survival at the first 5 years: > su = summary(survfit(Surv(a[, Date], a[, Event]) ~ strata(a[,Prediction]), data = a), times=c(0,1,2,3,4,5)) I have studied two kind of events (disease-free

Dear R users, I d like to assess the effect of "treatment" covariate on a disease relapse risk with the package cmprsk. However, the effect of this covariate on survival is time-dependent (assessed with cox.zph): no significant effect during the first year of follow-up, then after 1 year a favorable effect is observed on survival (step function might be the correct way to say that ?).

Hello, I have a problem regarding calculation of Cumulative Incidence Function. The event of interest is failure of bone-marrow transplantation, which may occur due to relapse or death in remission. The data set that I have consists of- lifetime variable, two indicator variables-one for relapse and one for death in remission, and the other variables are donor type (having 3 categories), disease

R-helpers: I have a dataset that has 168 subjects and 12 variables. Some of the variables have missing data and I want to use the multiple imputation capabilities of the "mice" package to address the missing data. Given that mice only supports linear models and generalized linear models (via the lm.mids and glm.mids functions) and that I need to fit Cox models, I followed the previous

Hi Bert, I am sorry to bother you on weekend. I am still struggling on defining a correct function. I first defined the function RFS (see below), then run it by provide the two argument. m52.2cluster <-RFS(inputfile =allinfo_m52, N=2 ) I do not get error message, but no figure displays on screen. I do not know what is going on. Can you help me a little more on this issue? Thank you,

FAQ 7.22 You must print a ggplot object, for example with print(m52.2cluster) For the FAQ, run the line system.file("../../doc/FAQ") in R on your computer. Open up the resulting filepath in your favorite editor and scroll down to 7.22 On Sun, Jan 14, 2018 at 4:21 PM, Ding, Yuan Chun <ycding at coh.org> wrote: > Hi Bert, > > I am sorry to bother you on weekend. >

Hi Richard, Thank you so much!! I understand the problem now, I assign a name to the "ggsurvplot" object and then add print(fig) at bottom of function definition, now figure gets printed on screen. Ding # function to generate RFS curves RFS <- function( inputfile, N ) { cluster<- survfit(Surv(RFS_days2, OV_Had_a_Recurrence_CODE) ~ clusters, data =

That is certainly OK, but you can also just use print(ggsurvplot(...)) as your final statement. out <- RFS( ...) would then return the ggsurvplot object *and* graph it. Any good R tutorial or a web search will provide more details on function returns, which you might find useful. Cheers, Bert Bert Gunter "The trouble with having an open mind is that people keep coming along and

Hello all, I am a medical student and as a capstone for my summer research project I am going to create a simple online web "calculator" for users to input their relevant data, and a probability of relapse within 5 years will be computed and returned based on the Cox PH model I have developed. The issue I'm having is finding a definitive method/function to feed the user's

Thank you, your suggestion is simpler and logically better. I had impression that the last object in a function gets returned, so I did not add the print function at the bottom line of the function definition. Returning an object and graph the object are different process, I am a beginner for writing R function and need to find a good guide source about writing R functions. If you know a good

Here is an example of how to do it. > library(survival) > vfit <- coxph(Surv(time, status) ~ celltype + trt, data=veteran) > userinput <- data.frame(celltype="smallcell", trt = 1) > usercurve <- survfit(vfit, newdata=userinput) #the entire predicted survival curve > user2 <- summary(usercurve, time= 2*365.25) # 2 year time point > user2$surv [1]

I'm trying to categorize a continuous variable (yes, I know that's horrible, but I'm trying to reproduce some exercises from a textbook) and don't really know an efficient way to do this. I have a data frame that looks like: surv_time relapse sex log_WBC rx 1 35 0 1 1.45 0 2 34 0 1 1.47 0 3 32 0 1 2.20 0 4 32

For any given pre-specified gene or short list of genes, yes the Cox model works fine. Two important caveats: 1. Remeber the rule of thumb for a Cox model of 20 events per variable (not n=20). Many microarray studies will have very marginal sample size. 2. If you are looking at many genes then a completely different strategy is required. There is a large and growing literature; I like Newton

Hello everyone, I am a very new user of R and I have a query about the cuminc function in the package cmprsk. In particular I would like to verify that I am interpreting the output correctly when we have a stratification variable. Hypothetical example: group : fair hair, dark hair fstatus: 1=Relapse, 2=TRM, 0=censored strata: sex (M or F) Our data would be split into: Fair, male,

Hello everyone,   I am a very new user of R and I have a query about the cuminc function in the package cmprsk. In particular I would like to verify that I am interpreting the output correctly when we have a stratification variable.   Hypothetical example:   group : fair hair, dark hair fstatus: 1=Relapse, 2=TRM, 0=censored strata: sex (M or F)   Our data would be split into:   Fair, male,

I am working with some survival data with missing values. I am using the mice package to do multiple imputation. I have found code in this thread which handles pooling of the MI results: https://stat.ethz.ch/pipermail/r-help/2007-May/132180.html Now I would like to plot a survival curve using the pooled results. Here is a reproducible example: require(survival) require(mice) set.seed(2) dt