similar to: R and FDA trials

I hope that Marc doesn't mind, but I felt that part of his recent post was important enough to deserve it's own subject line rather then being lost in a 60-msg-long thread... On Sun, Jan 11, 2009 at 10:08 AM, Marc Schwartz <marc_schwartz at comcast.net> wrote: ... I strongly believe that the comments regarding R and the FDA are overly negative and pessimistic. The hurdles to

I see in the archives significant discussion about SAS, CDISC formats etc. for FDA, but no direct suggestion of adding a write.xport method to the foreign package. Are there significant barriers to doing so? [[alternative HTML version deleted]]

https://gist.github.com/rpietro/6430771 stemDocument function doesn't seem to be working. Tried to look up and a few people have reported the problem, but no solution that I could find. would appreciate any help

I currently have a data set describing human subjects enrolled into an international clinical trial, the name of the hospital enrolling this human subject, the date when the subject was enrolled, and a vector with variables representing characteristics of the site (e.g., number of beds in a hospital). my data sets looks like this: subject hospital date_enrollment hospital_beds 1 hospitalA

Does anybody know if R is FDA or ICH (or EMEA...) compliant? AFAIK S-Plus is but that means nothing... -- Trebate bolji pristup internetu? Nazovite IskonInternet na 0800 1000 ili pogledajte http://www.iskon.biz/individualni/usluge/dialup/

Full_Name: David D Degras Version: 2.8.0 OS: Mac OS X Submission from: (NULL) (128.135.239.11) I have recently installed the version 2.8.0 of R along with package fda (v 2.0.2) and its dependencies (including package splines v. 2.8.0). Here are my problems: 1) The package splines should feature functions such a predict.bs, predict.bSpline and such and it does not! I can make calls to bs, ns,

Dear friends - I am trying to understand fda and working with the 2009 book from Springer. I run the scripts directly from a new installed fda library and include sessionInfo() below. This is from the script fdarm-ch09.R - I seem to have got not fda_2.2.8 but 2.2.7 - is that the problem? Where do I get .8 as I just reinstalled? Best wishes Troels Ring, Nephrology Aalborg, Denmark >

Dear All, I will soon be working with NIH and possibly FDA. Will I be able to use R or will I be forced to use SAS? Cheers, Federico -- Federico C. F. Calboli Department of Epidemiology and Public Health Imperial College, St. Mary's Campus Norfolk Place, London W2 1PG Tel +44 (0)20 75941602 Fax +44 (0)20 75943193 f.calboli [.a.t] imperial.ac.uk f.calboli [.a.t] gmail.com

Hi all there Can some one clarify me on this issue, features wise which is better R or SAS, leaving the commerical aspect associated with it. I suppose there are few people who have worked on both R and SAS and wish they would be able to help me in deciding on this. THank you for the help --------------------------------- [[alternative HTML version deleted]]

Hi, I am new to R, coming from a few years using Stata. I've been twisting my brain and checking several R and S references over the last few days to try to solve this data management problem: I have a data set with a unique patient identifier that is repeated along multiple rows, a variable with month of patient encounter, and a continous variable for cost of individual encounters. The data

Dear friends - We have 25 rats, 14 of these subjected to partial removal of kidney tissue, 11 to sham operation, and then followed for 6 weeks. So far we have data on 26 urine metabolites measured by NMR 7 times during the observation. I have smoothed the measurements by b.splines in fda including a roughness penalty, and inspecting the mean curves for nephrectomized and sham animals indicate

Dear all, There have been a variety of discussions on the R list regarding the use of R in clinical trials. The following post from the STATA list provides an interesting opinion regarding why SAS remains so popular in this arena: http://www.stata.com/statalist/archive/2008-01/msg00098.html Regards, -Cody Hamilton

Hello Everyone,   I’m a SAS user who has recently become interested in sequential clinical trials designs. I’ve discovered that the SAS based approaches for these designs are either too costly or are “experimental.” So now I’m looking for alternative software. Two programs that seem promising are SPLUS Seqtrial and R.   I recently obtained a 30 day trial for the SPLUS Seqtrial add-on and have

Hi, I found a discrepancy between results in R and Stata for a factor analysis with a promax rotation. For Stata: . *rotate, factor(2) promax* (promax rotation) Rotated Factor Loadings Variable | 1 2 Uniqueness -------------+-------------------------------- pfq_amanag~y | -0.17802 0.64161 0.70698 pfq_bwalk_~ø | 0.72569 0.05570

I would like to use R for submissions to FDA/CDRH (the medical device company I work for currently uses only SAS). Previous postings to the list regarding R and 21 CFR 11 compliance have been very helpful. However, reluctance to using open source software for statistical analyses and reporting remains high here at my company. Has anyone used R for an official submission to FDA/CDRH? It would

Dear All, I am fairly new to R. I work mainly in SAS. Now, I know that SAS is approved by the FDA for submissions. My question is, does the FDA approve {R} for clinical trial submissions. Also has anyone ever tried to produce TFL's using R. I would like to know how difficult it to produce the TFL's in R as compared to SAS. I know that in SAS it is not difficult once you know

rrdf is incredibly helpful, but I've notice that the rrdf package for mac hasn't been working for some time: http://goo.gl/5Ukpn . wondering if there is still a plan to maintain that in the long run, or if there is some other alternative to read RDF files. [[alternative HTML version deleted]]

fda 1.2.3 ======================== Version 1.2.3 of the fda package has just been released. This version adds to previous versions a script to create most of the figures of chapter 6 of "Applied Functional Data Analysis" by Ramsay and Silverman. Other changes offer simpler calls to time warping / registration and functional principal component functions. The fda package supports the

Hi all, I am setting up a new AD server with Samba 4.1.11 from the FreeBSD ports. I struggle with the internal DNS. I add a new CNAME record but it does not show up properly. I gave the AD domain a new DNS domain (domain.fda) and the server the name samba4.domain.fda. I am using the internal DNS, and a forwarder to a bind server in the same network. After the AD provision I have this here

The fda package supports "Functional Data Analysis" and "Applied Functional Data Analysis" by Bernard Silverman and James Ramsay. Functional data analysis, which lots of us like to call "FDA", is about the analysis of information on curves or functions. FDA is a collection statistical techniques for answering questions like, "What are the main ways in which the