similar to: Simulation of the Frailty of the Cox PH model

Hello, I want to generate data set from Cox PH model with gamma frailty effects. theta(parameter for frailty distribution)=2 beta=1.5 n=300 cluster size=30 number of clusters=10 I think I should first generate u from Gamma(Theta,theta) and then using this theta I could not decide how I should generate the survival times? Is there any package for this? or any document you could suggest? Any

Dear List, How do I extract the approximate Wald test for the frailty (in the following example 17.89 value)? What about the P-values, other Chisq, DF, se(coef) and se2? How can they be extracted? ######################################################> kfitm1 Call: coxph(formula = Surv(time, status) ~ age + sex + disease + frailty(id, dist = "gauss"), data = kidney)

Dear List, In documents (Therneau, 2003 : On mixed-effect cox models, ...), as far as I came to know, coxme penalize the partial likelihood (Ripatti, Palmgren, 2000) where as frailtyPenal (in frailtypack package) uses the penalized the full likelihood approach (Rondeau et al, 2003). How, then, coxme and coxph(...frailty(id, dist='gauss')) differs? Just the coding algorithm, or in

Dear All, I am attempting to make predictions based on a survreg() model with some censoring and a frailty term, as below: predict works fine on the original data, but not if I specify newdata. # a model with groups as fixed effect model1 <- survreg(Surv(y,cens)~ x1 + x2 + groups, dist = "gaussian") # and with groups as a random effect fr <- frailty(groups,

Dear all, Does the frailty.object$history[[1]]$theta returns the Variance of random effect? Why is the value different? Here is an example with kidney data: > library(survival) > data(kidney) > frailty.object<-coxph(Surv(time, status)~ age + sex + disease + frailty(id), kidney) > frailty.object Call: coxph(formula = Surv(time, status) ~ age + sex + disease + frailty(id), data

Dear all, I have been doing some frailty calculations and been facing some difficulties. I can extract coefficients, value of theta and the following things library(survival) fit<-coxph(Surv(time,status)~covariate+frailty(group), data=simulated.data) fit$coef fit$history[[1]]$theta fit$history[[1]]$c.loglik fit$var fit$var2 from a frailty included coxph object: but how can i know what other

Hi: I have a question about the use of the survfit function after the estimation of a cox proportional hazard model with a frailty term. My goal is to estimate expected survival probabilities while controlling for the group-specific frailty term. First, I estimate a model of the following form: model1 <- coxph(Surv(t0, t, d) ~ x1 + x2 + frailty(id), na.action=na.exclude,

Hello R users Would somebody know how to estimate survival from a frailty cox model, using the function survfit and the argument newdata ? (or from any other way that could provide individual expected survival with standard error); Is the problem related to how the random term is included in newdata ? kfitm1 <- coxph(Surv(time,status) ~ age + sex + disease + frailty(id,

Dear List, Can anyone please explain the difference between cluster() and frailty() in a coxph? I am a bit puzzled about it. Would appreciate any useful reference or direction. cheers, Ehsan > marginal.model <- coxph(Surv(time, status) ~ rx + cluster(litter), rats) > frailty.model <- coxph(Surv(time, status) ~ rx + frailty(litter), rats) > marginal.model Call: coxph(formula =

Dear all, Does R or S-plus or any of their packages provide Non-parametric "Run test" (which tests whether a sequence of numbers might be random or not)? If yes, i'd like a numerical illustration of this test. Any response / help / comment / suggestion will be greatly appreciated. Thanks in advance. ------------------------------- Mohammad Ehsanul Karim <wildscop at

Dear List, Trying to explain my situation as simply as possible for me: I am running a series of iteration on coxph model on simulated data (newly generated data on each iteration to run under coxph; in my example below- sim.fr is the generated data). However, sometimes i get warning messages like "Ran out of iterations and did not converge" or "Error in var(x, na.rm = na.rm) :

Dear list, I have been trying to use coxme in R 2.3.1. When I use coxme in the following data sim.fr1, i get "Warning messages: using 'as.environment(NULL)' is deprecated" Why does it occur? How can I hide such warning message, especially when coxme is under a loop? Mohammad Ehsanul Karim (Institute of Statistical Research and Training, University of Dhaka) >

Dear all, Does R or S-plus or any of their packages provide any command to form any of the following procedures to find Best Regression Equation - 1. 'All Possible Regressions Procedures' (is there any automated command to perform 2^p regressions and ordering according to criteria R2(adj), mallows Cp, s2- by not setting all the regression models manually), 2. 'Backward

Dear all, I am thinking of writing my own functions in s-plus (or in R). I just know how to work with S-plus / R built-in functions. Therefore, I'm a beginner in S programming. I am looking for some on-line documentation that is well written about "Programming in S language" where control stuctures / loops / vectorization and necessery sequences of S programming are

Hello, I am currently trying to simulate data and analyze it using the frailty option in the coxph function. I am working with recurrent event data, using counting process notation. Occasionally, (about 1 in every 100 simulations) I get the following warning: Error in coxph(Surv(start, end, censorind) ~ binary + uniform + frailty(subject, : X matrix deemed to be singular; variable 2 My

I am trying to build a model to aid a clinical decision. Certain patients have a blood marker measured at each visit - a rise of this may indicate recurrence of the cancer after treatment (endpoint is "clinical recurrence", censored). In a proportion (up to 30%), this rise is a false positive - hence I wish to correlate factors at the time of the rising test to clinical recurrence,

I am confused on how the log-likelihood is calculated in a parametric survival problem with frailty. I see a contradiction in the frailty() help file vs. the source code of frailty.gamma(), frailty.gaussian() and frailty.t(). The function frailty.gaussian() appears to calculate the penalty as the negative log-density of independent Gaussian variables, as one would expect: >

Hello, I was hoping that someone could answer a few questions for me (the background is given below): 1) Can the coxph accept an interaction between a covariate and a frailty term 2) If so, is it possible to a) test the model in which the covariate and the frailty appear as main terms using the penalized likelihood (for gaussian/t frailties) b)augment model 1) by stratifying on the variable that

Dear all, I have a data set<http://yaap.it/paste/c11b9fdcfd68d02b#gIVtLrrme3MaiQd9hHy1zcTjRq7VsVQ8eAZ2fol1lUc=>with 6 clusters, each containing 48 (possibly censored, in which case "event = 0") survival times. The "x" column contains a binary explanatory variable. I try to describe that data with a gamma frailty model as follows: library(survival) mod <-

On Tue, 6 May 2003, Jerome Asselin wrote: > > I am confused on how the log-likelihood is calculated in a parametric > survival problem with frailty. I see a contradiction in the frailty() help > file vs. the source code of frailty.gamma(), frailty.gaussian() and > frailty.t(). > > The function frailty.gaussian() appears to calculate the penalty as the > negative