similar to: cat bailing out in a for loop

Hi everyone, I'm using the function 'HWE.exact' of 'genetics' package to compute p-values of the HWE test. My data set consists of ~600 subjects (cases and controls) typed at ~ 10K SNP markers; the test is applied separately to cases and controls. The genotypes are stored in a list of 'genotype' objects, all.geno, and p-values are calculated inside the loop over all

Hi, I have a genotype data for both case and controls and would like to calculate the HW p-value. However, since the number of one genotype is 0, I got wired result. Would someone help me to figure it out? Or confirm it's right? Thanks a lot. ============ > library( "genetics" ) NOTE: THIS PACKAGE IS NOW OBSOLETE. The R-Genetics project has developed an set of enhanced

The "genetics" package for handling single-locus genetic data is now available on CRAN in both source and Windows binary formats. The purpose of this package is to make it easy to create and manipulate genetic information, and to facility use of this information in statistical models. The library includes classes and methods for creating, representing, and manipulating genotypes

The "genetics" package for handling single-locus genetic data is now available on CRAN in both source and Windows binary formats. The purpose of this package is to make it easy to create and manipulate genetic information, and to facility use of this information in statistical models. The library includes classes and methods for creating, representing, and manipulating genotypes

Dear All, The following code extracts from NCBI very nice output for ONE allele of a SNP (often the allele with the second largest frequency - usually termed the minor allele). It gives an average minor allele frequency from all NCBI sources (which is what I want, except I'd like the addition of data for all the other alleles of one SNP) plus a table of minor allele frequencies from each

Hello! First of all I must appologize if this has been raised previously, but search provided by Robert King at the University of Newcastle seems to be down these days. Additionally let me know if such a question should be sent to R-help. I did a contribution to function hwe.hardy in package 'gap' during the weekend. That functions performs Hardy-Weinberg equilibrium test using MCMC. The

Hi, I am new to R. and even though I've made my code to run and do what it needs to . It is taking forever and I can't use it like this. I was wondering if you could help me find ways to fix the code to run faster. Here are my codes.. the data set is a bunch of 0s and 1s in a data.frame. What I am doing is this. I pick a column and make up a new column Y with values associated with that

Hi, I cant understand where I am going wrong.Below is my code.I would really appreciate your help. Thanks. > genfile<-read.table("c:/tina/phd/bs871/hw/genfile.txt",skip=1) > > #read in SNP data > snp.dat <- as.matrix(genfile) > snp.name <- scan("c:/tina/phd/bs871/hw/genfile.txt",nline=1,what="character") Read 100 items

Hi, I am having trouble compiling package gap http://www.hgmp.mrc.ac.uk/~jzhao/r-progs.htm on Tiger. I have installed XcodeTools 2.1. The binary version of gap currently available on CRAN has some bug and is fixed in the latest version. The message I get from R is below. Any help is greatly appreciated. best regards, Kenny Ye tar: Read 1536 bytes from - * Installing *source* package

Hi, Following my earlier posts about having problems performing a PCA, I have worked out what the problem is. The problem lies within the PLINK to gds conversion. It seems as though the SNPs are imported as "samples" and in turn, the samples are recognised as SNPs: >snpsgdsSummary("chr2L") Some values of snp.position are invalid (should be > 0)! Some values of

*Combining 2 columns into 1 column many times in a very large dataset* The clumsy solutions I am working on are not going to be very fast if I can get them to work and the true dataset is ~1500 X 45000 so they need to be efficient. I've searched the R help files and the archives for this list and have some possible workable solutions for 2) and 3) but not my question 1). However, I include

Hello, I need some help with the simulatedSNPs function from scrime package. I am trying to simulate some genotype of a case/control disease locus. The allele frequence are cases/controls Sample cases controls 2000 .5 .10 1500 .6 .40 In each of the row, i need to simulate 100 snp and calculate the pvalue ##############Download Scrime

Hello, I did a pca with over 200000 snps for 340 observations (ids). If I plot the eigenvectors (called rotation in prcomp) 2,3 and 4 (e.g. plot (rotation[,2]) I see a strange "column" in my data (see attachment). I suggest it is an artefact (but of what?). Suggestion: I used prcomp this way: prcomp (mat), where mat is a matrix with the column means already substracted followed by a

Dear R-experts, My problem is how to handle a 10GB data file containing genotype data. The file is in a particular format (Illumina final report) and needs to be altered and merged with phenotype data for further analysis. PERL seems to be an frequently used solution for this type of work, however I am inclined to think it should be doable with R. How do I open a text-file, line by line,

Hi All, I have a list of matrices: > x [,1] [,2] [1,] 1 4 [2,] 2 5 [3,] 3 6 > y [,1] [,2] [,3] [,4] [,5] [,6] [1,] 18 21 24 27 30 33 [2,] 19 22 25 28 31 34 [3,] 20 23 26 29 32 35 > z =list(x,y) I want to create a second list that is has a subset each matrix in the list subsetting so I get the 2nd and 3rd row of each (and

Hi all, We are using two methods to identify SNPs. One is based on resequencing the genome and aligning the reads to the sequenced genome to identify SNPs (data available for 44 individuals). Another is based on SNP array with selected loci (30000 loci, 870 individuals). I want to compare the results from the resequencing based minor allele frequency and Array based minor allele frequency.

Dear All, I saved by mistake the environment I was working in after typing q(), and now I get the annoying message: [Previously saved workspace restored] I have already deleted all the objects in the environment, saving it as an empty environment, so it's just a matter of nitpicking I suppose. The message does not appear if I start R from any other place in the directory tree. I am

Hi All, I have a vector of data, a vector of bin breakpoints and I want to put my data in the bins and then extract fanciful informations like the mean value of each bin. I know I can write my own function, but I would have thought that R should have somewhere a function that took as arguments something like (data, breaks, what to do with the data in the bins). I surey could not find it

Hi, I have been finding clues on the internet to understand the reason for this warning. The package i have made, builds, installs and works well, except for this warning when I check it: When I run: R CMD check mypack_1.0.tar.gz ... ... .. .. * checking R code for possible problems ... NOTE Found possibly global 'T' or 'F' in the following functions: HWE procRef readMartFile

Hi All, a colleague wants to calculate the Fisher information matrix for a model he wrote (not in R). He can easily get the neg-log-likelihood and the best fit parameters at the minimum. He can also get negLLs for other parameter values too. Given these data, is there a way in R to calculate the Fisher information matrix? Best, Federico -- Federico C. F. Calboli Department of Epidemiology