similar to: Hardy Weinberg

Hello, I am trying to simulate 10 relicates of 100-tables. Each table is a 2 x 3 and 80% pf the tables are true nulls and 20% are non-nulls. The nulls follow the Hardy Weinberg distribution (ratio) 1:2:1. I have the code below but the p-values are not what I am expecting. I want to use the Cochran Armitage trend test to get the p-values. num.reps=10 num.vars=1000 pi0 = 80 num.subjects = 100

Hi, I am using the gap R package to do the Hardy Weinberg Case Control test for many SNP. I am not sure what the values initial1 and initial2 should be for the test. I tried values but they failed. I emailed the author but to no avail. There seems to be some documentation that is deleted at the top, if anyone can direct me how to get this I will be grateful. -- Thanks, Jim. [[alternative HTML

Dear All, I am trying to calculate the Hardy-Weinberg Equilibrium p-value for 42 SNPs. I am using the function HWE.exact from the package "genetics". In order not to do a lot of coding "by hand", I have a for loop that goes through each column (each column is one SNP) and gives me the p.value for HWE.exact. Unfortunately some SNP have reached fixation and HWE.exact requires a

Hello, I have indicators for the present of absent of a snps in columns and the categorey (case control column). I would like to extract ONLY the tables and the indices (SNPS) that give me 2 x 3 tables. Some gives 2x 2 tables when one of the allelle is missing. The data look like the matrix snpmat below: so the first snp should give me the following table: (aa=0, Aa=1 and AA=2) aa

Hi, I have a genotype data for both case and controls and would like to calculate the HW p-value. However, since the number of one genotype is 0, I got wired result. Would someone help me to figure it out? Or confirm it's right? Thanks a lot. ============ > library( "genetics" ) NOTE: THIS PACKAGE IS NOW OBSOLETE. The R-Genetics project has developed an set of enhanced

Hi everyone, I'm using the function 'HWE.exact' of 'genetics' package to compute p-values of the HWE test. My data set consists of ~600 subjects (cases and controls) typed at ~ 10K SNP markers; the test is applied separately to cases and controls. The genotypes are stored in a list of 'genotype' objects, all.geno, and p-values are calculated inside the loop over all

I a using plink on a large SNP dataset with a .map and .ped file. I want to get some sort of file say a list of all the SNPs that plink is saying that I have. ANyideas on how to do this? -- Thanks, Jim. [[alternative HTML version deleted]]

Hello, I did a pca with over 200000 snps for 340 observations (ids). If I plot the eigenvectors (called rotation in prcomp) 2,3 and 4 (e.g. plot (rotation[,2]) I see a strange "column" in my data (see attachment). I suggest it is an artefact (but of what?). Suggestion: I used prcomp this way: prcomp (mat), where mat is a matrix with the column means already substracted followed by a

snpMatrix package is quite nice (read.plink())

Hello! First of all I must appologize if this has been raised previously, but search provided by Robert King at the University of Newcastle seems to be down these days. Additionally let me know if such a question should be sent to R-help. I did a contribution to function hwe.hardy in package 'gap' during the weekend. That functions performs Hardy-Weinberg equilibrium test using MCMC. The

Dear all, I want to simulate from the null distribution of the following 2 x 3 table, 2 5 10 4 8 5 I am using a chi-squared test. Anyone has any idea how to do this? -- Thanks, Jim. [[alternative HTML version deleted]]

Hi, Following my earlier posts about having problems performing a PCA, I have worked out what the problem is. The problem lies within the PLINK to gds conversion. It seems as though the SNPs are imported as "samples" and in turn, the samples are recognised as SNPs: >snpsgdsSummary("chr2L") Some values of snp.position are invalid (should be > 0)! Some values of

Bottom Line Up Front: How does one reshape genetic data from long to wide? I currently have a lot of data. About 180 individuals (some probands/patients, some parents, rare siblings) and SNP data from 6000 loci on each. The standard formats seem to be something along the lines of Famid, pid, fatid, motid, affected, sex, locus1Allele1, locus1Allele2, locus2Allele1, locus2Allele2, etc In other

Hi All, I have a problem with weighted logistic regression. I have a number of SNPs and a case/control scenario, but not all genotypes are as "guaranteed" as others, so I am using weights to downsample the importance of individuals whose genotype has been heavily "inferred". My data is quite big, but with a dummy example: > status <- c(1,1,1,0,0) > SNPs <-

The "genetics" package for handling single-locus genetic data is now available on CRAN in both source and Windows binary formats. The purpose of this package is to make it easy to create and manipulate genetic information, and to facility use of this information in statistical models. The library includes classes and methods for creating, representing, and manipulating genotypes

The "genetics" package for handling single-locus genetic data is now available on CRAN in both source and Windows binary formats. The purpose of this package is to make it easy to create and manipulate genetic information, and to facility use of this information in statistical models. The library includes classes and methods for creating, representing, and manipulating genotypes

Hi, I'm simulating a Markov chain in Fortran interfaced with R-2.2.1 in order to generate data according to a Markov Random Field called the Potts model. R Version: platform i686-pc-linux-gnu arch i686 os linux-gnu system i686, linux-gnu status major 2 minor 2.1 year 2005 month 12 day 20 svn rev 36812 Each loop of my Fortran calls the function rmultinom.c

>>>>> Christophe Dutang >>>>> on Sat, 8 Apr 2023 14:21:53 +0200 writes: > Dear all, > Using rmultinom() in a stochastic model, I found this function returns an error message 'NA in probability' for an infinite probability. > Maybe, a more precise message will be helpful when debugging. >> rmultinom(1, 3:5, c(1/2, 1/3,

On 08/04/2023 5:53 p.m., Martin Maechler wrote: >>>>>> Christophe Dutang >>>>>> on Sat, 8 Apr 2023 14:21:53 +0200 writes: > > > Dear all, > > > Using rmultinom() in a stochastic model, I found this function returns an error message 'NA in probability' for an infinite probability. > > > Maybe, a more

Dear all, Using rmultinom() in a stochastic model, I found this function returns an error message 'NA in probability' for an infinite probability. Maybe, a more precise message will be helpful when debugging. > rmultinom(1, 3:5, c(1/2, 1/3, Inf)) Error in rmultinom(1, 3:5, c(1/2, 1/3, Inf)) : NA in probability vector > rmultinom(1, 3:5, c(1/2, 1/3, NA)) Error in rmultinom(1,