similar to: DRC: Effective doses versus Predicted values

Dear R Community, I am using the package DRC ( to fit a boltzman model to my data. I can fit the model and extract the lower limit, upper limit, and ED50 (aka V50), but I cannot figure out how to get the slope of the curve at ED50. Is there a simple way to do this? I've searched the mailing list and looked through the package documentation, but could not find anything. I am new to r, and

Hi, I am trying to use drc package to calculate IC50 value. The ED50 calculated in some models (LL4 for example) as a response half-way between the upper and lower limit, which is the definition of the relative IC50 value. Does that mean the ED50 in drc package is IC50? How the ED function in drc package distinguish to estimate ED or IC values? Thanks a lot [[alternative HTML version

Hello, We use drc to fit dose-response curves, recently we discovered that there are quite different standard error values returned for the same dataset depending on the drc-version / R-version that was used (not clear which factor is important) On R 2.9.0 using drc_1.6-3 we get an IC50 of 1.27447 and a standard error on the IC50 of 0.43540 Whereas on R 2.7.0 using drc_1.4-2 the IC50 is

Gday, This is a repost since I only had one direct reply and I remain mystified- This may be stupidity on my part but it may not be so simple. In brief, my problem is I'm not sure how to extract parameter values/effect sizes from a nonlinear regression model with a significant interaction term. My data sets are dose response curves (force and dose) for muscle that also have two

G'day, My problem is I'm not sure how to extract effect sizes from a nonlinear regression model with a significant interaction term. My data sets are multiple measurements of force response to an agonist with two superimposed treatments each having two levels. This is very similar to the Ludbrook example in Venables and Ripley. The experiment is that a muscle is exposed to an agonist

I am using semiparametric Model  library(mgcv) sm1=gam(y~x1+s(x2),family=binomial, f) How should I  find out standard error for ed50 for the above model ED50 =( -sm1$coef[1]-f(x2)) / sm1$coef [2]   f(x2) is estimated value for non parametric term.   Thanks [[alternative HTML version deleted]]

Hi R-Users, I have plotted a region whose polygon coordinates are given in shp format ED50 UTM (zone=30) ) using "readShapePoly" in library(maptools). Now I need to plot a set of points in that region (my.dataframe, with X and Y geographic coordinates), which have been read using GPS in Longitud-Latitud form (using WGS84 system), so I first need to convert these Longitud-Latitud data

I am working with Probit regression (I cannot switch to logit) can anybody help me in finding out how to obtain with R Finney's fiducial confidence intervals for the levels of the predictor (Dose) needed to produce a proportion of 50% of responses(LD50, ED50 etc.)? If the Pearson chi-square goodness-of-fit test is significant (by default), a heterogeneity factor should be used to calculate

Dear all, I can use the very nice drc package (multdrc()) to model and plot a dataframe containing dose and response values. I can also use predict.drc() to yield response values given a dose. I need to do the opposite, estimate a dose given the response. The general predict documentation seems to say that this is possible, but it does not appear that predict.drc has that capability.

Hello, I am trying to fit my Elisa results (absorbance readings) to a standard curve. To create the standard curve model, I performed a 4-parameter logistic fit using the 'drc' package (ExpectedConc~Absorbance). This gave me the following: > FourP A 'drc' model. Call: drm(formula = Response ~ Expected, data = SC, fct = LL.4()) Coefficients: b:(Intercept) c:(Intercept)

Hi there, I am attempting to analyse data from a crossover study using a mixed effect Emax model in R using nlme. I am having problems ascertaining how to fit the model. Subjects are randomly assigned to 1 of 4 treatments in a complete block design. The response variable of interest is recorded once within each period. So, subjects have a response for each period. Specifically, I want to fit

thanks a lot Renaud. but i was interested in Finney's fiducial confidence intervals of LD50 so to obtain comparable results with SPSS. But your reply leads me to the next question: does anybody know what is the best method (asymptotic, bootstrap etc.) for calculating confidence intervals of LD50? i could "get rid" of Finney's fiducial confidence intervals but

After a run multdrc comment in R program, show warning sign in this program. I attached the saving page of the script. I hope you could help me, please. Thanks a lot A. Rahbari -------------- next part -------------- R : Copyright 2005, The R Foundation for Statistical Computing Version 2.1.0 (2005-04-18), ISBN 3-900051-07-0 R is free software and comes with ABSOLUTELY NO WARRANTY. You are

I have the following problem. I have measured a dose response curve (binary response, continuous dose) on a grid of x,y positions. I would like to produce a grey-level plot that shows the LD50 at each (x,y) position. I am thinking that I have to do something like fit<-glm(resp ~ x*y + dose, family = binomial) Corrections welcome. But from here I don't know how to get LD50, and certainly

Dear R users, I'm a little lost on how to define pmodels for the DRC package. My goals are to produce isoboles of binary toxicity data. any tips? I really just need to know what pmodels refers to. Cheers, Pat -- View this message in context: http://r.789695.n4.nabble.com/pmodels-in-DRC-tp4190567p4190567.html Sent from the R help mailing list archive at Nabble.com.

Hi, I am currently trying to do dose-response curves using weighted 4-parameter model (4PL). The weighting was based on 1/(expected variance) derived from historical data. I tried both drm() from drc package, and nls(), found very different results derived from drm() vs. nls() using "weights=" argument. d1<-read.table("d1.txt",sep='\t',header=T,row.names=1)

R-helpers, I am using the package "drc" to fit a 4 parameter logistic model. When I use the predict function to get prediction on a new dataset, I am not getting the requested confidence or prediction intervals. Any idea what is going on? Here is code to reproduce the problem: --- library(drc) # Fit model to existing dataset in package spinach.model <- drm(SLOPE~DOSE, data =

Hi every one, I am using the package 'drc' to model root elongation using dose response data. I don't know which model I should use. Though I don't know which model I should use, I tried the following codes given below. But it produced the error messages.Can any one tell me the code in 'drc' package to find out the EC (Effective Concentration) values and Confidence

On Fri, 18 May 2018, Ed Siefker wrote: > I have dose response data I have analyzed with the 'drc' package. > Using plot() works great. I want to arrange my plots and source > data on a single page. I think 'gridExtra' is the usual package for > this. > > I could use plot() and par(mfrow=...), but then I can't put the source > data table on the page. >

I have dose response data I have analyzed with the 'drc' package. Using plot() works great. I want to arrange my plots and source data on a single page. I think 'gridExtra' is the usual package for this. I could use plot() and par(mfrow=...), but then I can't put the source data table on the page. gridExtra provides grid.table() which makes nice graphical tables. It