similar to: Nested frailty model

Dear List, In documents (Therneau, 2003 : On mixed-effect cox models, ...), as far as I came to know, coxme penalize the partial likelihood (Ripatti, Palmgren, 2000) where as frailtyPenal (in frailtypack package) uses the penalized the full likelihood approach (Rondeau et al, 2003). How, then, coxme and coxph(...frailty(id, dist='gauss')) differs? Just the coding algorithm, or in

Dear R-help, I am trying to estimate a Cox model with nested effects basing on the minimization of the overall AIC; I have two frailties terms, both gamma distributed. There is a error message (theta2 argument misses) and I don?t understand why. I would like to know what I have wrong. Thank you very much for your time. fitM7 <- coxph(Surv(lifespan,censured) ~ south + frailty(id,

Dear List, Can anyone please explain the difference between cluster() and frailty() in a coxph? I am a bit puzzled about it. Would appreciate any useful reference or direction. cheers, Ehsan > marginal.model <- coxph(Surv(time, status) ~ rx + cluster(litter), rats) > frailty.model <- coxph(Surv(time, status) ~ rx + frailty(litter), rats) > marginal.model Call: coxph(formula =

Dear all, This probably stems from my lack of understanding of the model, but I do not understand the variance of the random effect reported in coxme. Consider the following toy example: #------------------------------- BEGINNING OF CODE ------------------------------------------------ library(survival) library(coxme) #--- Generate toy data: d <- data.frame(id = c(1:100), #

Dear all, I have a data set<http://yaap.it/paste/c11b9fdcfd68d02b#gIVtLrrme3MaiQd9hHy1zcTjRq7VsVQ8eAZ2fol1lUc=>with 6 clusters, each containing 48 (possibly censored, in which case "event = 0") survival times. The "x" column contains a binary explanatory variable. I try to describe that data with a gamma frailty model as follows: library(survival) mod <-

Hello, I am running R 2.6.1 on windows xp I am trying to fit a cox proportional hazard model with a shared Gaussian frailty term using coxme My model is specified as: nofit1<-coxme(Surv(Age,cen1new)~ Sex+bo2+bo3,random=~1|isl,data=mydat) With x1-x3 being dummy variables, and isl being the community level variable with 4 levels. Does anyone know if there is a way to get the standard error

Dear R users: I'm generating the following survival data: set.seed(123) n=200 #sample size x=rbinom(n,size=1,prob=.5) #binomial treatment v=rgamma(n,shape=1,scale=1) #gamma frailty w=rweibull(n,shape=1,scale=1) #Weibull deviates b=-log(2) #treatment's slope t=exp( -x*b -log(v) + log(w) ) #failure times c=rep(1,n) #uncensored indicator id=seq(1:n) #individual frailty indicator

Does someone know the rules by which 'coxph' returns 'frail', the predicted frailty terms? In my test function: ----------------------------------------------- fr <- function(){ #testing(frailty terms in 'survival' require(survival) dat <- data.frame(exit = 1:6, event = rep(1, 6), x = rep(c(0, 1), 3),

Hi: I have a few clarification questions about the elements returned by the coxph function used in conjuction with a frailty term. I create the following group variable: group <- NULL group[id<50] <- 1 group[id>=50 & id<100] <- 2 group[id>=100 & id<150] <- 3 group[id>=150 & id<200] <- 4 group[id>=200 & id<250] <- 5 group[id>=250

Hi: I have a question about the use of the survfit function after the estimation of a cox proportional hazard model with a frailty term. My goal is to estimate expected survival probabilities while controlling for the group-specific frailty term. First, I estimate a model of the following form: model1 <- coxph(Surv(t0, t, d) ~ x1 + x2 + frailty(id), na.action=na.exclude,

Dear list, I want o fit a shared gamma frailty model with the frailty specification in the survival package. I have partly left-truncated data and time-dependent covariates. Is it possible to combine these two things in the frailty function. Or are the results wrong if I use data in the start-stop-formulation which account for delayed entry? Is the frailty distribution updated in the

Dear R-users, I have noticed small discrepencies in the reported estimate of the variance of the frailty by the print method for survreg() and the 'theta' component included in the object fit: # Examples in R-2.6.2 for Windows library(survival) # version 2.34-1 (2008-03-31) # discrepancy fit1 <- survreg(Surv(time, status) ~ rx + frailty(litter), rats) fit1 fit1$history[[1]]$theta

Dear All, The "coxph" function in the "survival" package allows multiple frailty terms. In all the examples I saw, however, the frailty terms are nested. What will happen if I have non-nested (that is, cross-classified) frailties in the model? Will the model still work? Do I need to take special cares when specifying these models? Thanks! Shige [[alternative HTML

Hello, I am working on the frailty model using coxph functions. I am running some simulations and want to store the variance of frailty (theta) values from each simulation result. Can anyone help me how to extract the theta values from the results. I appreciate any help. Thanks Shankar Viswanathan

Assume that we collect below data : - subjects = 20 males + 20 females, every single individual is independence, and difference events = 1, 2, 3... n covariates = 4 blood types A, B, AB, O http://r.789695.n4.nabble.com/file/n4245397/CodeCogsEqn.jpeg ?m = hazards rates for male ?n = hazards rates for female Wm = Wn x ?, frailty for males, where ? is the edge ratio of male compare to female Wn =

Hello, I'm trying to estimate a cox model with a frailty variable and time-dependent covariate (below there is the statement I use and the error message). It's seems to be impossible, because every time I add the time-dependent covariate the model doesn't converge. Instead, if I estimate the same model without the time-dependent covariate it's converge. I'd like knowing if

Hi, I have a question about the output for variance of random effect from a gamma frailty model using coxph in R. Is it the vairance of frailties themselves or variance of log frailties? Thanks. Guanghui

Hola! I started to search for information about multilevel survival models, and found frailty in R. This seems to be something of the same, is it the same? Then: why the name frailty (weekness?) -- Kjetil Halvorsen. Peace is the most effective weapon of mass construction. -- Mahdi Elmandjra

I can't comment on frailtypack issues, but would like to mention that coxme will handle nested models, contrary to the statement below that "frailtypack is perhaps the only .... for nested survival data". To reprise the original post's model cgd.nfm <- coxme(Surv(Tstart, Tstop, Status) ~ Treatment + (1 | Center/ID), data=cgd.ag) And a note to the poster-- you should

Dear List, How do I extract the approximate Wald test for the frailty (in the following example 17.89 value)? What about the P-values, other Chisq, DF, se(coef) and se2? How can they be extracted? ######################################################> kfitm1 Call: coxph(formula = Surv(time, status) ~ age + sex + disease + frailty(id, dist = "gauss"), data = kidney)