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...ven though I am not using the S4 class and method concepts here, I am getting this error. I have also uploaded the input file on which the normalization needed to be performed. Hence, I would be grateful for you if you can give some direction/advice for me to overcome this error. Thanks a lot, Suprabhath Reddy http://www.nabble.com/file/p16190637/textE_to_affy.csv textE_to_affy.csv -- View this message in context: http://www.nabble.com/Error-in-function-%28classes%2C-fdef%2C-mtable%29%3A-unable-to-find-an-inherited-method-for-function-%22indexProbes%22%2C-for-signature-%22exprSet%22%2C-%22charac...