search for: pharmacologi

Dear all, at the Division of Clinical Pharmacology at the University of Cape Town (South Africa) we are looking for highly motivated science/engineering PhD graduates to join our pharmacometrics group as a post-doctoral fellow. Pharmacometrics is an emerging discipline that applies mathematical modelling and simulation to pharmacology, aiding the interpretation of data from clinical trials,

This is probably easy for experienced users but I could not find a solution. I have several R scripts that process several columns of a dataframe (several dataframes and columns actually, but simplified for my question). References such as: myDF$myCol are all over. I like to automate this for other dataframes and columns by defining a reference only once in the beginning of the script. One

Dear R users - I have a list of patient identifiers and diagnoses from inpatient admissions. I would like to reorganize the list, presently in a long format to a wide format in reshape, but in the absence of a "time" element, I am uncertain how to do this - any help greatly appreciated. ID Dx A nausea A diabetes A kidney failure A heart attack A fever B fever B

Dear R-project team, I have tried but could not install the R statistical package (http://cran.ms.unimelb.edu.au/ ) even after the help of my institute's IT personnel. The setup file could not be downloaded. The latest file R-2.12.2.tar.gz<http://cran.ms.unimelb.edu.au/src/base/R-2/R-2.12.2.tar.gz> does not start installation wizard. Kindly extend the technical support. Best regards.

Dear all, Our pharmacometrics group is looking for bright and motivated candidates to join our modelling team within the Division of Clinical Pharmacology at the University of Cape Town. Our group has established PK/PD modelling expertise in the disease areas of tuberculosis, HIV, and malaria. It is active internationally and enjoys on-going collaborations and exchange programs with some of the

Dear R-listers, I am an enthusiastic new to R and have the following simple (. I hope .) problem: I am searching a function that allows to import jpg files as matrices (n x m x 3) i.e. n_pixels x m_pixels x 3_colors. I have seen the pixmap library, but it seems able only to read BMP pictures (and not all them .). Can someone give me some suggestions ? Thank you in advance.

Hi, I am looking for any procedure in R to fit "Latent variables models" in particular "Latent trait models (i.e. for binary data)". could anyone help me? Many thanks , Dr Abderrahim Oulhaj Oxford University Department of Pharmacology Mansfield Road Oxford OX1 3QT Tel: +44 1865 224098 Fax: +44 1865 224099 Email: abderrahim.oulhaj@pharmacology.oxford.ac.uk

Hi all, I have successfully compiled and installed (OS: Linux Mandrake 9.2) the last devel version of R (ver. 1.9.0). All seems to go well, but now I cannot use the cursors for exploring back the command history (when I press the cursor key the following characters are shown: ^[[A , or ^[[B etc.). Hints and suggestions are welcomed. Thanks. Paolo -- ----------------------------- Paolo

Hello, I am trying to fit a nlme (non linear mixed effect). I am using the SelfStart function SSlogis. However the data in my hand contains few observations per subject (4 or less), so the nlsList doesn't work... In this case I should fixe initial parameter estimates. I remark that values of initial estimates have a greater effect on the model fit (i.e. loglikelihood, AIC and also on

Hi everyone, Does the selfstart function SSlogis of the "nlme" library allows the introduction of time varying covariates ? For example how can I interpret the xmid parameter (reperesenting the age at which we reach the half of the asymptote) if I want to explain it by a some time varying covariate? Thanks in adavance, Abderrahim Abderrahim Oulhaj, Phd in Statistics Oxford

Dear R, I am attempting to install 2.0.1 on a Debian system and getting an error that appeared for people installing 2.0.0. Warning message: package seems to be using lazy loading already in: makeLazyLoading("tools") Error in get(x, envir, mode, inherits) : variable ".install_package_description" was not found Execution halted platform i686-pc-linux-gnu arch i686 os

Hi I've just installed the R version 2.10.1 on my new PC and unfortunately I have problem to use the function Estimables. I have downloaded gmodels succesfully but have problems when I activate the package. I get following meassage; > utils:::menuInstallLocal() package 'gmodels' successfully unpacked and MD5 sums checked > local({pkg <-

Dear all, We are looking for bright and motivated candidates to join our pharmacometric modelling team at the University of Cape Town. Pharmacometrics is an emerging discipline that uses mathematical and statistical tools to quantify drug, disease, and trial information to aid efficient drug development and/or regulatory decisions. It designs and applies mathematical models to describe the

Greetings! I am trying to figure out how to order a data frame by one variable conditioned on another. Here is an example of what I have: d <- data.frame(RUN = rep(1:3, each = 3), ID = 1:9, AUC = runif(9,1,100)) > d RUN ID AUC 1 1 70.2 1 2 86.5 1 3 20.1 2 4 74.3 2 5 53.6 2 6 67.6 3 7 99.9 3 8 47.3 3 9 41.3

The Quantitative Decision Strategies group at Janssen Research & Development, Johnson & Johnson, is looking for a candidate to represent QDS in Beijing, China in the subsidiary company of Xian-Janssen Pharmacetical Ltd. The basic requirements for this candidate are 1) 3+ years experience in a quantitative field, but not necessarily pharmaceutical; 2) PhD in statistics or related field

Dear R Helpers, I have imported an SPSS file that contains date data. The data appear in R in a numeric format, as follows: 10485849600 10477641600 10561104000 10562745600 etc. I'd be extremely grateful if someone could tell me how to make these numbers into comprehensible dates! Thanks, Jonathan Williams

Dear R helpers, I have a largish matrix (1300 x 1300) and I wish to find the row and column numbers that identify particular elements whose values I know in advance (for example, the row and column numbers for the maximum value of the matrix). I have looked in the help manual and found the functions 'row' and 'col' for finding the indices of a matrix. But, I can't figure out

All, For data consisting of serial measurements on subjects, one may use the aggregate function to say compute the peak response for each subject for each design condition. Is there a way to alter this or another one-liner to also retain the time at which the peak occurred and thus avoid writing a doing this via a loop? I suppose one could attempt to employ the split function but that's

¡Hola! ¿Alguien sabe si existe una función en R que devuelve el nombre del área de trabajo (workspace) en uso si éste ha sido guardado anteriormente? Con getwd() R me devuelve la carpeta de trabajo, pero si en ésta tengo varios áreas de trabajo guardados, p.e. a.RData y b.RData, ¿cómo podría saber en cuál estoy trabajando si por un despiste no me acordara cuál he abierto anteriormente (sin tener

TOP Institute Pharma (TI Pharma) has granted our proposal to set up a mechanism-based PKPD modelling platform. This platform focuses on the transfer of knowledge from academia to the pharmaceutical industry and is a collaborative effort of four excellent academic institutes and six leading global pharmaceutical industries. Unique to this platform is the availability of shared databases on