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Alternate title: How can I persuade my students that R is for them? Alternate title: Can R replace SAS, SPSS or Stata for clinicians? I am teaching introductory statistics to twelve physicians and two veterinarians who have enrolled in a Mentored Clinical Research Training Program. My course is the first in a sequence of three. We (the instructors of this sequence) chose to teach R rather than some other computing environment...

I am trying to develop a prognostic model using logistic regression. I built a full , approximate models with the use of penalization - design package. Also, I tried Chi-square criteria, step-down techniques. Used BS for model validation. The main purpose is to develop a predictive model for future patient population. One of the strong predictor pertains to the study design and would not

I've got a 20 slide Powerpoint set up against the expected day someone says "Mitch, could you talk for a short while to the residents on how to use statistics?" It looks good at this end, but I'd love to get at least one more pair of eyes on it. Any volunteers? -- Due to the recession, requests for instant gratification will be deferred until arrears in scheduled

Thanks for sharing the questions and responses! Is it possible to appreciate how much the coefficients matter in one or the other model? Say, using Biau's example, using coxph, as.factor(grade2 == "high")TRUE gives hazard ratio 1.27 (rounded). As clinician I can grasp this HR as 27% relative increase. I can relate with other published results. With survreg the Weibull model gives a

...nterpretation of complex datasets (see, for example, http://xmap.picr.man.ac.uk ). The ideal candidate will be excited by the interface between computer science, mathematics and biology, and will have a strong desire to see their work applied directly in collaboration with both bench-scientists and clinicians. Significant programming experience is a pre-requisite and applications from candidates with strong R programming skills are particularly encouraged. Full details are here: http://www.paterson.man.ac.uk/jobs/viewjob.asp?Job=PI/07/20 regards Crispin --------------------------------------------...

...ons are available for postdoctoral researchers with experience analysing high throughput genomic data and/or a detailed knowledge of genome annotation and gene structure. The ideal candidate will have a PhD in Bioinformatics, Computational Biology (or a related discipline), enjoy working alongside clinicians and biologists on complex real-world datasets, and will have significant experience using tools such as R/Bioconductor, Matlab, Perl Java and SQL. Bioinformatics Programmer ------------------------- We are seeking a software engineer to build novel databases and Bioconductor/R software for the ana...

We are finding more and more clinical researchers interested in learning R and are starting to teach R to clinicians. We have put some teaching material on our site: http://biostat.mc.vanderbilt.edu -- Frank E Harrell Jr Professor and Chair School of Medicine Department of Biostatistics Vanderbilt University

Check out the gpls package on CRAN. HTH, Andy > From: Min-Han Tan > > Good morning, > > Thank you all for your help so far. I really appreciate it. > > The crux of my problem is that I am generating a generalized linear > model with 1 dependent variable, approximately 50 training samples and > 100 parameters (gene levels). > > Essentially, if I have 100

...ee, for example, http://xmap.picr.man.ac.uk <http://xmap.picr.man.ac.uk/> ). The ideal candidate will be excited by the interface between computer science, mathematics and biology, and will have a strong desire to see their work applied directly in collaboration with both bench-scientists and clinicians. Significant programming experience is a pre-requisite and applications from candidates with strong R programming skills are particularly encouraged. Full details are here: http://www.paterson.man.ac.uk/jobs/viewjob.asp?Job=PI/07/20 <http://www.paterson.man.ac.uk/jobs/viewjob.asp?Job=PI/07/20&g...

...wendt; wade brian Sent: Sunday, December, 2004 5:58 AM Subject: feel youthful Antibiotic treatment is nearly always instituted empirically and is often continued with no isolate to direct specific treatment Most trials assessed this scenario and do not support a benefit for combination therapy Clinicians may still opt for combination empirical treatment to increase the probability of appropriate empirical treatment which has indeed been shown to improve survival 90 91 Current evidence suggests that aminoglycoside monotherapy may be inadequate for infections outside the urinary tract 10 92 93 You mi...

The Child and Adolescent Mental Health Services (CAMHS) Evidence Based Practice Unit (EBPU) is a dynamic, expanding and friendly academic and service development unit, currently consisting of 19 people including: researchers, clinicians and service development specialists (http://www.ucl.ac.uk/clinical-psychology/EBPU/). It is part of University College London (UCL) and the Anna Freud Centre (AFC), with main offices based at AFC in leafy North West London. The unit undertakes research helping develop effective service provision fo...

...ation of selected opportunities • Ensuring proper knowledge and awareness of innovative methods and designs: help identify, develop, organize, provide and/or arrange training and presentations on innovative approaches across the Development organization (including statisticians, modelers, clinicians, and other stakeholder groups) to ensure awareness and adequate knowledge about these methods. Keep up-to-date knowledge of designs and analysis methods for clinical trials, including adaptive designs, model-based methods, etc. • External collaborations, visibility, and impact: engage in ex...

...formatting output, and generating figures and tables to meet precise requirements. Experience in SAS programming related to clinical drug development. Able to provide programming at the protocol and project level and contribute to cross-functional teams consisting of statisticians, data managers, clinicians and other computer programmers on drug development projects. Academic training in computing or a scientific discipline; MS/A or equivalent (at least 4 years relevant experience with demonstrated experience processing data from multiple protocols). Demonstrated ability to communicate ideas and some...

Hi all, I came across this article on LinuxMedNews (http://www.linuxmednews.com) this morning: http://www.linuxmednews.com/linuxmednews/1076524250/index_html This refers to an integrated data management and analysis system (OIO), which includes R and utilizes the RSessionDA package (Greg Warnes). More information is available here for those interested:

...sent composed by six Heads of Department and one Head of Programme. Supervision of currently five statisticians and of PhD-students and young researchers at the Institute is required. Ability to collaborate with individual researchers and research groups within and outside our institute, including clinicians and laboratory researchers at treatment centres, is necessary. Required qualifications Your research background should be on a postdoctoral level, preferably on a professor level. You must hold extensive knowledge in theoretical statistics and also have attained substantial practical experienc...

...computational biology projects is to develop machine learning methods for the mining of big ?omics? data in biology. Our overarching goal is to develop personalized medicine that uses genetic information to tailor therapy for individual patients. Collaboration with an interdisciplinary team (e.g. clinicians and biologists) is an essential component in our projects. 2. Health Care Analytics effort focuses on advancing the state of the art through development of advanced algorithms as well as deployment of real world tools that can be applied effectively across a number of users scenarios. 3. A mobile...

...the purpose of mechanism-based PK-PD model building. As underscored in the Critical Path to New Medicines report by the FDA, our models are essential to revert the current attrition rate of new drugs and will result in less in vivo testing, increase effectiveness of clinical trials and will assist clinicians in the treatment of progressive diseases and of vulnerable patients such as children. This public private research partnership is a collaborative effort of four outstanding Dutch academic partners: the University of Leiden, the University of Groningen, the University Medical Center of Utrecht, the...

...opment of novel algorithms relevant to the analysis of high throughput assays. Responsibilities (May include some or all of the following): 1. Analysis: a. Identify current computational bottlenecks in data analysis for specific assays b. Communicate with statisticians, laboratory scientists, clinicians, programmers and information systems staff to understand and develop requirements and specifications for analysis datasets and analysis programs. c. Develop novel computational algorithms that outperform state-of-the art algorithms d. Create, document and validate programs, data, data pipelines,...

Hello, I have a problem regarding calculation of Cumulative Incidence Function. The event of interest is failure of bone-marrow transplantation, which may occur due to relapse or death in remission. The data set that I have consists of- lifetime variable, two indicator variables-one for relapse and one for death in remission, and the other variables are donor type (having 3 categories), disease

Hi All, I am running a scatter plot and trying to add a best fit line. I use an abline function, but get no line drawn over the points. I also get no error. I arm using V 2.10.0 on Windows 7. Here is my code, including the SAS transport file import: require (foreign) require (chron) require (Hmisc) require (lattice) clin <- sasxport.get("y:\\temp\\subset.xpt") attach(clin)